High-throughput-compatible assays using a genetically-encoded calcium indicator.

Measurement of intracellular calcium in live cells is a key component of a wide range of basic life scienceresearch, and crucial for many high-throughput assays used in modern drug discovery. Synthetic calcium indicators have become the industry standard, due their ease of use, high reliability, wide dynamic range, and availability of a large variety of spectral and chemical properties.

Genetically-encoded calcium indicators (GECIs) have been optimized to the point where their performance rivals that of synthetic calcium indicators in many applications. Stable expression of a GECI has distinct advantages over synthetic calcium indicators in terms of reagent cost and simplification of the assay process.

EIA Buffer 10X
22040030-1 50 mL
EUR 35.74

EIA Buffer 10X
22040030-2 100 mL
EUR 58.1

Laminin EIA Kit
GWB-783B25 ELISA_Kits Ask for price

Cortisol EIA Kit
EK7119 96wells/kit
EUR 370
Description: Quantitative colorimetric detection of cortisol. 96wells/kit.

Cortisol EIA Kit
MBS480401-1Kit 1Kit
EUR 325

Cortisol EIA Kit
MBS480401-5x1Kit 5x1Kit
EUR 1430

Cortisol EIA Kit
SKT-201-96 1 plate of 96 wells
EUR 219.75

AquaBlock/EIA/WB
ND-R0998 1 Each Ask for price

Histamine EIA Kit
MBS480395-1Kit 1Kit
EUR 730

Histamine EIA Kit
MBS480395-5x1Kit 5x1Kit
EUR 3340

Estradiol EIA Kit
MBS480404-1Kit 1Kit
EUR 410

Estradiol EIA Kit
MBS480404-5x1Kit 5x1Kit
EUR 1825

Fibronectin EIA Kit
GWB-F363CE ELISA_Kits Ask for price

Isoprostane EIA Kit
MBS480409-1Kit 1Kit
EUR 410

Isoprostane EIA Kit
MBS480409-5x1Kit 5x1Kit
EUR 1825

Lixisenatide - EIA Kit
EK-028-08 96 wells
EUR 603.72

Progesterone EIA Kit
MBS480406-1Kit 1Kit
EUR 410

Progesterone EIA Kit
MBS480406-5x1Kit 5x1Kit
EUR 1825

Testosterone EIA Kit
MBS480407-1Kit 1Kit
EUR 410

Testosterone EIA Kit
MBS480407-5x1Kit 5x1Kit
EUR 1825

EIA-3025-YL AB Labels
049330 Box of 4500 Label(s)
EUR 62.31
Description: Description Dutch: Inspectiepijlen op kaart; Description French: Flèches d'inspection sur carte

EIA-3025-WT AB Labels
049331 Box of 4500 Label(s)
EUR 62.31
Description: Description Dutch: Inspectiepijlen op kaart; Description French: Flèches d'inspection sur carte

EIA-3025-RD AB Labels
049332 Box of 4500 Label(s)
EUR 62.31
Description: Description Dutch: Inspectiepijlen op kaart; Description French: Flèches d'inspection sur carte

Corticosterone EIA kit
MBS480402-1Kit 1Kit
EUR 530

Corticosterone EIA kit
MBS480402-5x1Kit 5x1Kit
EUR 2380

Corticosterone EIA Kit
SKT-205-96 1 plate of 96 wells
EUR 194.25

Androstenedione EIA Kit
MBS480403-1Kit 1Kit
EUR 395

CYFRA 21-1 EIA [CE]
211-10 48 Tests Ask for price

DM1 ADC EIA Kit
DEIABL311 96T Ask for price
Description: tissue cell cultures, serum

GIP (Rat) - EIA Kit
EK-027-12 96 wells
EUR 603.72

GLP-2 EIA, Rat
KT-373 96 test
EUR 1038

9 (+) - HODE EIA Kit
MBS480408-INQUIRE INQUIRE Ask for price

MMAE ADC EIA Kit
DEIABL312 96T Ask for price
Description: tissue cell cultures, serum

MMAF ADC EIA Kit
DEIABL313 96T Ask for price
Description: tissue cell cultures, serum

CanAg CEA EIA [CE]
401-10 96 Tests Ask for price
Description: CanAg CEA EIAis intended for the quantitative determination of squamous cell carcinoma (SCC) antigen in serum as an aid in the management of patients with squamous cell carcinoma

CanAg NSE EIA [CE]
420-10 96 Tests Ask for price
Description: TheCanAg NSE EIAtest is in solid phase. This non-competitive immunoassay is based on two monoclonal antibodies (from mice) directed against two separate antigenic determinants of the NSE molecule. The monoclonal antibodies (Mab) used relate to the  subunit of the enzyme, and therefore detect bothϒϒandαϒforms. Calibrators and patient samples are incubated together, with biotinylated Anti-NSE Mab E21 and raIFO/rt peroxidase (HRP) labelled Anti-NSE Mab E17, in Streptavidin-coated microtiter strips

CanAg AFP EIA [CE]
600-10 96 Tests Ask for price
Description: TheCanAg AFP EIAkit is intended for the quantitative dertermination ofα-Fetoprotein (AFP) in human serum. CanAg EIA a solid-phase test. This non-competitive immunoassay is based on the direct sandwich technique. Calibrators, Controls and Patient samples are incubated together with biotinylated Anti-AFP monoclonal antibody and RaIFO/rt Peroxidase (HRP) labeled Anti-AFP monoclonal antibody, in Streptavidin-coated microtiter strips. After washing, the buffered Substrate / Chromogen reagent (hydroge

CanAg SCC EIA [CE]
800-10 96 Tests Ask for price
Description: The CanAg Squamous Cell Carcimoma ELISA kit is intended for the qualitative derminoation of squamous ccell carcinoma (SCC) antigen in serum as an aid in the management of patines wiht squamous cell carcinoma. CanAg SCC EIAis in solid phase. This non-competitive immunoassay is based on the direct sandwich technique. Calibrators and Patient samples are incubated together with biotinylated Anti-SCC Monoclonal Antibody and RaIFO/rt Peroxidase (HRP) labeled Anti-SCC Monoclonal Antibody, in Streptavid

GIP (Human) - EIA Kit
EK-027-02 96 wells
EUR 603.72

GLP-2 EIA, Mouse
KT-374 96 test
EUR 1038

GLP-2 EIA, Human
KT-385 96 test
EUR 1038

CanAg S100 EIA [CE]
708-10 96 Tests Ask for price
Description: TheCanAg S100 EIAkit is intended for the quantitative determination ofS100B (S100A1B + S100BB)in serum. CanAg S100 EIA is in solid phase. This non-competitive, two-step immunoassay is based on two mouse monoclonal antibodies, specific for the two different epitopes expressed in S100B. The test determines both S100A1B and S100BB, without cross-reactivity with other forms of S100. Calibrators and patient samples are incubated together with a biotinylated monoclonal antibody Anti-S100B (MAb) S23, i

Cyclic AMP EIA Kit
SKT-209-96 1 plate of 96 wells
EUR 544.8
Description: Direct EIA kit used for quantitative measuring cAMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic GMP EIA Kit
SKT-211-96 1 plate of 96 wells
EUR 568.8
Description: Direct EIA kit used for quantitative measuring cGMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Tissue Culture Media samples from all species

ACTH (Human) - EIA Kit
EK-001-01 96 wells
EUR 603.72

CGRP (Human) - EIA Kit
EK-015-02 96 wells
EUR 603.72

Alarin (Rat) - EIA Kit
EK-026-33 96 wells
EUR 603.72

Lipoxin A4 EIA Kit
MBS480399-1Kit 1Kit
EUR 730

Lipoxin A4 EIA Kit
MBS480399-5x1Kit 5x1Kit
EUR 3340

CanAg CA242 EIA [CE]
101-10 96 Tests Ask for price
Description: TheCanAg CA242 EIAis a solid-phase, non-competitive immunoassay based on thedirect sandwich technique. Calibrators, controls and patient samples are incubated together with biotinylated anti-CA242 monoclonal antibody (MAb) C241 in Streptavidin coated microstrips. CA242 present in calibrators, controls or samples is absorbed to the Streptavidin coated microstrips by the biotinylated anti-CA242 MAb during the incubation. The strips are then washed and incubated with horseradish peroxidase (HRP) la

CanAg CA125 EIA [CE]
400-10 96 Tests Ask for price
Description: TheCanAg CA125EIA kit is intended for the quantitative dertermination of thecancer associated antigen C125 in Serum CanAg CA125 EIA is a solid-phase test. This non-competitive immunoassay is based on the direct sandwich method. Calibrators, Controls and Patient samples are incubated together with a biotinylated Anti-CA125 (mouse) monoclonal antibody (Mab) OV 197 in Streptavidin-coated microtiter strips. CA125, present in Calibrators or samples, is absorbed onto Streptavidin-coated strips by biot

Cystatin C EIA Kit
SKT-219-96 1 plate of 96 wells
EUR 592.8
Description: Sandwich EIA kit used to measure cystatin C levels in Serum, EDTA Plasma, Heparin Plasma, Urine, Tissue Culture Media samples from Human

INSL5 (Mouse) - EIA Kit
EK-035-40 96 wells
EUR 707.4

Human TRAP-5b EIA
KT-652 96 tests
EUR 760

CanAg ProGRP EIA [CE]
220-10 96 Tests Ask for price
Description: TheCanAg ProGRP EIAkit assay is to be used as an aid in the differential diagnosis and in monitoring disease progession during the course of disease and treatment in smallcell lung cancer patients TheCanAg ProGRP EIAis a solid-phase, one-step, non-competitive immunoassay based on antibodies specific for different epitopes specifically expressed in ProGRP. Calibrators, controls or unknown samples are incubated together with affinity purified biotinylated Anti-ProGRP polyclonal antibody and horser

Alarin (Human) - EIA Kit
EK-026-34 96 wells
EUR 603.72

Spadin (Human) - EIA Kit
EK-049-72 96 wells
EUR 660.96

Secretin (Rat) - EIA Kit
EK-067-06 96 wells
EUR 603.72

EIA Buffer for ELISA
GR103069 100 mL
EUR 69

Calcitonin (Rat) - EIA Kit
EK-014-06 96 wells
EUR 603.72

Secretin (Human) - EIA Kit
EK-067-03 96 wells
EUR 603.72

Secretin (Mouse) - EIA Kit
EK-067-04 96 wells
EUR 603.72

Urocortin 2 EIA, Mouse
KT-376 96 test
EUR 1038

Urocortin (Human) - EIA Kit
EK-019-14 96 wells
EUR 603.72

Endomorphin-1 - EIA Kit
EK-044-10 96 wells
EUR 603.72

Endomorphin-2 - EIA Kit
EK-044-11 96 wells
EUR 603.72

Prostaglandin E2 EIA Kit
SKT-207-96 1 plate of 96 wells
EUR 632.4
Description: Sandwich EIA kit used for quantitative measuring PGE2 present in Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Leu-Enkephalin - EIA Kit
EK-024-21 96 wells
EUR 603.72

Calcitonin (Salmon) - EIA Kit
EK-014-09 96 wells
EUR 603.72

Secretoneurin (Rat) - EIA Kit
EK-047-95 96 wells
EUR 629.64

Urinary Isoprostane EIA Kit
MBS480410-1Kit 1Kit
EUR 410

Urinary Isoprostane EIA Kit
MBS480410-5x1Kit 5x1Kit
EUR 1825

Adrenomedullin (Human) - EIA Kit
EK-010-01 96 wells
EUR 629.64

proSex peptide (28-55) - EIA Kit
EK-040-31 96 wells
EUR 603.72

Pancreastatin (Porcine) - EIA Kit
EK-053-08 96 wells
EUR 603.72

Lixisenatide - Fluorescent EIA Kit
FEK-028-08 96 wells
EUR 660.96

Lixisenatide - Chemiluminescent EIA Kit
CEK-028-08 96 wells
EUR 660.96

BNP-32 (Rat) - EIA Kit
EK-011-14 96 wells
EUR 603.72

BNP-45 (Rat) - EIA Kit
EK-011-17 96 wells
EUR 603.72

APL1 beta 28 - EIA Kit
EK-018-42 96 wells
EUR 603.72

CanAg PSA EIA kit [CE]
340-10 96 Tests Ask for price
Description: TheCanAg PSA EIAkit is intended for the quantitative determination of Total PSA (Prostate Specific Antigen) in human serum. Dertermination of PSA is now widely used for detection and management of patients withprostatic cancerand conidered as the superior serological marker for cancer of the prostate. TheCanAg PSA EIAis a non-competitive solid-phase immunoassay based on the direct sandwich technique. Calibrators, Controls and patient samples are incubated together with biotinylated Anti-PSA mono

ANP (Rat, Mouse) - EIA Kit
EK-005-24 96 wells
EUR 603.72

CGRP II (Human) - EIA Kit
EK-015-07 96 wells
EUR 603.72

CanAg CA19-9 EIA [CE]
120-10 96 Tests Ask for price
Description: TheCanag CA 19-9is intended for the quantitative determination of thecancerassociaciated antigen CA-19-9 in Serum TheCanAg CA19-9 EIAis a solid-phase, non-competitive immunoassay based upon the direct sandwich technique. Calibrators, controls and patient samples are incubated together with a biotinylated Anti-CA19-9 monoclonal antibody (MAb) C192 (derived from mice) in streptavidin coated microstrips. CA19-9 present in calibrators or samples is adsorbed to the streptavidin coated micro- strips b

CanAg CA15-3 EIA [CE]
200-10 96 Tests Ask for price
Description: TheCanAg CA15-3 EIAkit is intended for the quantitative dertermination of thecancer associated antigen MUC-1(CA15-3) in serum. the CanAg CA15-3 EIAis a solid-phase, non-competitive immunoassay based upon the direct sandwich technique. Calibrators, controls and patient samples are incubated together with biotinylated Anti-CA15-3 monoclonal antibody and horse-radish peroxidase (HRP) labelled Anti-CA15-3 monoclonal antibody in Streptavidin coated microstrips. After washing, buffered Substrate/Chrom

CanAg Free PSA EIA [CE]
350-10 96 Tests Ask for price
Description: TheCanAg Free PSA EIAis intended for the quantitative dertermination ofFree PSA (Prostate Specific Antigen)in human Serum. TheCanAg Free PSA EIAis a non-competitive solid-phase immunoassay based on the direct sandwich technique. Calibrators, controls and patient samples are incubated together with a biotinylated Anti-PSA Libre monoclonal antibody and raIFO/rt peroxidase (HRP) labeled Anti-PSA monoclonal antibody, in Streptavidin-coated microtiter strips. After washing, the buffered Substrate/Chr

ACTH (Rat, Mouse) - EIA Kit
EK-001-21 96 wells
EUR 603.72

BNP-32 (Human) - EIA Kit
EK-011-03 96 wells
EUR 603.72

BNP-45 (Mouse) - EIA Kit
EK-011-23 96 wells
EUR 603.72

CGRP (Rat, Mouse) - EIA Kit
EK-015-09 96 wells
EUR 603.72

Peptide YY (PYY) EIA, Rat
KT-370 96 test
EUR 998

SeaBlock EIA/WB w/ PBS
ND-R0996 1 Each Ask for price

TLQP-21 (Human) - EIA Kit
EK-003-90 96 wells
EUR 603.72

BNP-32 (Canine) - EIA Kit
EK-011-22 96 wells
EUR 603.72

BNP-32 (Porcine) - EIA Kit
EK-011-10 96 wells
EUR 603.72

Amylin (Rat, Mouse) - EIA Kit
EK-017-11 96 wells
EUR 603.72

Gastrin I (Human) - EIA Kit
EK-027-04 96 wells
EUR 603.72

Relaxin 2 (Human) - EIA Kit
EK-035-62 96 wells
EUR 604.8

Urotensin II (Rat) - EIA Kit
EK-071-09 96 wells
EUR 645.84

Peptide YY (PYY) EIA, Human
KT-378 96 test
EUR 998

Amylin / IAPP (Human) - EIA Kit
EK-017-03 96 wells
EUR 603.72

C-Peptide (Human) - EIA Kit
EK-035-01 96 wells
EUR 603.72

Apelin-36 (Human) - EIA Kit
EK-057-15 96 wells
EUR 645.84

Apelin-55 (Human) - EIA Kit
EK-057-42 96 wells
EUR 594

SeaBlock/EIA/WB with Tris
ND-R0997 1 Each Ask for price

Human E-cadherin EIA Kit
GWB-40B393 ELISA_Kits Ask for price

Urocortin II (Human) - EIA Kit
EK-019-30 96 wells
EUR 603.72

Endorphin, beta (Rat) - EIA Kit
EK-022-33 96 wells
EUR 603.72

Urotensin II (Human) - EIA Kit
EK-071-05 96 wells
EUR 645.84

Urotensin II (Mouse) - EIA Kit
EK-071-08 96 wells
EUR 645.84

GIP (Rat) - Fluorescent EIA Kit
FEK-027-12 96 wells
EUR 660.96

Urocortin (Rat, Mouse) - EIA Kit
EK-019-15 96 wells
EUR 603.72

Endorphin, beta (Human) - EIA Kit
EK-022-14 96 wells
EUR 603.72

Cortistatin-14 (Rat) - EIA Kit
EK-060-04 96 wells
EUR 603.72

Cortistatin-29 (Rat) - EIA Kit
EK-060-05 96 wells
EUR 603.72

GIP (Human) - Fluorescent EIA Kit
FEK-027-02 96 wells
EUR 660.96

Salusin-alpha (Human) - EIA Kit
EK-010-67 96 wells
EUR 603.72

Proghrelin-94 (Human) - EIA Kit
EK-032-63 96 wells
EUR 603.72

ACTH (Human) - Fluorescent EIA Kit
FEK-001-01 96 wells
EUR 660.96

CGRP (Human) - Fluorescent EIA Kit
FEK-015-02 96 wells
EUR 660.96

Endorphin, beta (Porcine) - EIA Kit
EK-022-32 96 wells
EUR 603.72

Pancreastatin 29 (Human) - EIA Kit
EK-053-36 96 wells
EUR 603.72

Cortistatin-17 (Human) - EIA Kit
EK-060-11 96 wells
EUR 603.72

Cortistatin-29 (Human) - EIA Kit
EK-060-12 96 wells
EUR 603.72

96-Well EIA Microtiter Plate
MBS258056-1Plate 1Plate
EUR 115

96-Well EIA Microtiter Plate
MBS258056-5x1Plate 5x1Plate
EUR 335

OneBlock™ EIA Blocking Buffer
20-315 1000ml/Unit
EUR 146.05
Description: For ELISA

INSL5 (Mouse) - Fluorescent EIA Kit
FEK-035-40 96 wells
EUR 799.2

Calcitonin (Human, Monkey) - EIA Kit
EK-014-03 96 wells
EUR 603.72

Secretin (Porcine, Bovine) - EIA Kit
EK-067-05 96 wells
EUR 603.72

EIA Wash Buffer 10x concentrate
1003-1 1 Liter
EUR 277.2

Alarin (Human) - Fluorescent EIA Kit
FEK-026-34 96 wells
EUR 660.96

Mouse Alpha2 Antiplasmin EIA kit
MBS480472-1Kit 1Kit
EUR 825

Mouse Alpha2 Antiplasmin EIA kit
MBS480472-5x1Kit 5x1Kit
EUR 3755

Ghrelin (Human) - Fluorescent EIA Kit
FEK-031-30 96 wells
EUR 660.96

Ghrelin (Canine) - Fluorescent EIA Kit
FEK-031-50 96 wells
EUR 660.96

Copeptin (Human) - Fluorescent EIA Kit
FEK-065-32 96 wells
EUR 660.96

Secretin (Human) - Fluorescent EIA Kit
FEK-067-03 96 wells
EUR 660.96

Secretin (Mouse) - Fluorescent EIA Kit
FEK-067-04 96 wells
EUR 660.96

Allopregnanolone EIA Kit (One Plate)
K044-H1 1x96 well plate
EUR 510

Urocortin (Human) - Fluorescent EIA Kit
FEK-019-14 96 wells
EUR 660.96

Endomorphin-1 - Fluorescent EIA Kit
FEK-044-10 96 wells
EUR 660.96

Endomorphin-2 - Fluorescent EIA Kit
FEK-044-11 96 wells
EUR 660.96

Allopregnanolone EIA Kit (Five Plate)
K044-H5 5x96 well plate
EUR 1788

Leu-Enkephalin - Fluorescent EIA Kit
FEK-024-21 96 wells
EUR 660.96

Catestatin (Human) - Fluorescent EIA Kit
FEK-053-27 96 wells
EUR 660.96

Pancreatic Polypeptide (Human) - EIA Kit
EK-054-02 96 wells
EUR 603.72

Calcitonin (Salmon) - Fluorescent EIA Kit
FEK-014-09 96 wells
EUR 660.96

Ghrelin (Human) - Chemiluminescent EIA Kit
CEK-031-30 96 wells
EUR 660.96

Urocortin (Human) - Chemiluminescent EIA Kit
CEK-019-14 96 wells
EUR 660.96

Endomorphin-2 - Chemiluminescent EIA Kit
CEK-044-11 96 wells
EUR 660.96

Adrenomedullin (Human) - Fluorescent EIA Kit
FEK-010-01 96 wells
EUR 692.28

SAA1(48-104)(Human) – EIA kit
EK-020-83 96 wells
EUR 579.96

Pancreastatin (Porcine) - Fluorescent EIA Kit
FEK-053-08 96 wells
EUR 660.96

Androstenedione ELISA Kit (Competitive EIA)
EK7019 96wells/kit, with removable strips.
EUR 550
Description: Androstenedione ELISA Kit, tested with Serum and Plasma. Format: 96 wells/kit.

Calcitonin (Salmon) - Chemiluminescent EIA Kit
CEK-014-09 96 wells
EUR 660.96

Amylin (1-13) (Human) - EIA Kit
EK-017-06 96 wells
EUR 603.72

Simian SRV EIA, 48 Tests/Kit
4812 each
EUR 390

TLQP-21 (Rat, Mouse) - EIA Kit
EK-003-89 96 wells
EUR 603.72

[Arg34]-GLP-2 (Human) - EIA Kit
EK-028-14 96 wells
EUR 568.08

GLP-1 EIA, Human, Mouse, Rat
KT-384 96 test
EUR 998

Adrenomedullin (Human) - Chemiluminescent EIA Kit
CEK-010-01 96 wells
EUR 660.96

Simian STLV EIA, 48 Tests/Kit
4813 each
EUR 390

[pGlu1]-ELA-32 (Human) - EIA Kit
EK-007-19 96 wells
EUR 629.64

Peptide YY (PYY) (Human) - EIA Kit
EK-059-01 96 wells
EUR 617.76

Rat tPA EIA Active ELISA kit
MBS480459-1Kit 1Kit
EUR 820

Rat tPA EIA Active ELISA kit
MBS480459-5x1Kit 5x1Kit
EUR 3725

15-Epi-Lipoxin A4 EIA Kit
MBS480522-1Kit 1Kit
EUR 730

15-Epi-Lipoxin A4 EIA Kit
MBS480522-5x1Kit 5x1Kit
EUR 3340

BNP-26 (Porcine, Ovine) - EIA Kit
EK-011-08 96 wells
EUR 603.72

sFNDC4 (Human, Rat, Mouse) - EIA Kit
EK-067-91 96 wells
EUR 778.68

Urocortin 3 EIA, Mouse and Rat
KT-377 96 test
EUR 1038

Simian Measles EIA, 48 Tests/Kit
4814 each
EUR 390

DetectX® ANP EIA Antibody, 3ML
C262-3ML 3ML
EUR 254

INSL3 C-Peptide (Human) - EIA Kit
EK-035-48 96 wells
EUR 707.4

INSL7 C-Peptide (Human) - EIA Kit
EK-035-52 96 wells
EUR 603.72

Betatrophin (139-198) (Human) - EIA Kit
EK-051-55 96 wells
EUR 660.96

Betatrophin (133-198) (Mouse) - EIA Kit
EK-051-57 96 wells
EUR 660.96

Ghrelin (human, mouse, rat) EIA Kit
K4790-100 100 assays
EUR 946.8
Description: Sensitive, Colorimetric Assay

DetectX® ANP EIA Antibody, 13ML
C262-13ML 13ML
EUR 840

We generated a clonal cell line constitutively expressing GCaMP6s; high expression of the GECI was driven by coupling to a blasticidin resistance gene with a self-cleaving cis-acting hydrolase element (CHYSEL) 2A peptide. Here, we compared the performance of the GECI GCaMP6s to the synthetic calcium indicator fluo-4 in a variety of assay formats. We demonstrate that the pharmacology of ion channel and GPCR ligands as determined using the two indicators is highly similar, and that GCaMP6s is viable as a direct replacement for a synthetic calcium indicator.